Jamie Maguire, PhD
Kenneth and JoAnn G. Wellner Professor
Graduate School of Biomedical Sciences
A major focus of the research program in the Maguire Lab involves elucidating the physiological, pathological, and pharmacological mechanisms mediating transitions between network and behavioral states. Ongoing projects focus on the role of GABAergic interneurons in coordinating network activity in the basolateral amygdala (BLA) and identifying inputs onto these neurons which can exert control over the network and the communication of behavioral outputs. We are investigating the pharmacological (alcohol and neurosteroids), pathological (epilepsy), and context-dependent (stress) transitions between network and behavioral states. Our research involves a systems-level approach, investigating the impact of stress, a major risk factor for psychiatric disorders, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction on networks implicated in mood. Our goal is to understand the pathophysiological mechanisms contributing to disease in an effort to identify novel targets for therapeutic intervention.
Cummings, K., & Maguire, J. (2022). Interneurons direct circuit-specific flow of information to communicate stressful experiences. Neuron, 110(6), 911–913. https://doi.org/10.1016/j.neuron.2022.02.019. PMID: 35298916.
Ragan, C. M., Ahmed, E. I., Vitale, E. M., Linning-Duffy, K., Miller-Smith, S. M., Maguire, J., & Lonstein, J. S. (2022). Postpartum State, but Not Maternal Caregiving or Level of Anxiety, Increases Medial Prefrontal Cortex GAD65 and vGAT in Female Rats. Frontiers in global women’s health, 2, 746518. https://doi.org/10.3389/fgwh.2021.746518. PMID: 35211693;PMCID: PMC8861351.
Maguire J. (2021). Mechanisms of Psychiatric Comorbidities in Epilepsy. Current topics in behavioral neurosciences, 10.1007/7854_2020_192. Advance online publication. https://doi.org/10.1007/7854_2020_192. PMID: 33723802.